Clinical pharmacology of antihypertensive agent. Future view of antihypertensive agents. Renin-angiotensin system depressant drugs.

Antihypertensive Treatment and Renal Protection: the role of drugs inhibiting the renin-angiotensin-aldosterone system

The prevalence of chronic kidney disease, currently estimated to vary between 8 and 12 % in the general population, is steadily rising due to aging and to the ongoing epidemic of hypertension and type 2 diabetes. Even in its early stages, chronic kidney disease entails a greater risk for cardiovascular mortality, and its prevention and treatment is rapidly becoming a key medical issue for many ...

CLINICAL PROGRESS Clinical Evaluation of Antihypertensive Drugs

T HE evaluation of antihypertensive drugs has become a big business. Hundreds of people who work in some aspect of clinical investigation spend at least part of their time in this process. Their observations determine the expenditure, first by the drug companies and then by the public, of some millions of dollars a year. Even the law recognizes the fact that no accumulation of pharmacology, how...

Angiotensin-(1-7) contributes to the antihypertensive effects of blockade of the renin-angiotensin system.

Angiotensin-converting enzyme (ACE) inhibition alone or in combination with the angiotensin type-I receptor (AT1) antagonist losartan augments circulating levels of the bioactive peptide angiotensin-(1-7) [Ang-(1-7)]. Hence, we determined whether Ang-(1-7) contributes to the hypotensive effects produced by the combined administration of lisinopril and losartan in spontaneously hypertensive rats...

THE EFFECT OF ANTIHYPERTENSIVE DRUGS IN THE SUPPRESSION OF ATHEROSCLEROSIS

The present investigation was undertaken to evaluate the effect of antihypertensive drugs on aortic atherogenesis in hypercholesterolemic rabbits. In enalapril and nifedipine treated rabbits aortic atherosclerotic plaque involvement was significantly decreased (p<0. Oland p<O. 05, respectively) as compared to the control group. However, in hydrochlorothiazide treated rabbits aortic atheroge...

Interactions between antihypertensive agents and other drugs.